연구 동향

Handbook of experimental pharmacology2026-11-03

표적 단백질 분해 개론

Introduction of Targeted Protein Degradation

EBioMedicine2026-11-02

자궁선근증의 진단 및 질병 치료 개선을 위한 잠재적 바이오마커 후보

Potential biomarker candidates for improving diagnosis and disease treatment in adenomyosis

Journal of ethnopharmacology2026-11-02

화시윤조탕이 쇠그렌증후군에서 RBM15B-관련 m6A 조절을 통해 타액샘 상피세포의 ferroptosis를 완화한다

Huashi Runzao Decoction alleviates ferroptosis in salivary gland epithelial cells through RBM15B-associated m(6)A regulation in Sjögren's disease

Molecular & cellular proteomics : MCP2026-11-02

EGFR/TBK1-의존성 미토콘드리아 품질 관리가 테모졸로마이드에 대한 획득 내성에 기여한다

EGFR/TBK1-dependent mitochondrial quality control contributes to acquired resistance to temozolomide

European journal of pharmacology2026-11-02

13β,21-dihydroeurycomanone이 RIG-1/Caspase-1/GSDMD 경로 활성화를 통해 폐선암 세포에서 pyroptosis를 유도한다

13β,21-dihydroeurycomanone induces pyroptosis in lung adenocarcinoma cells via activating RIG-1/Caspase-1/GSDMD pathway

Bone2026-11-02

GLP-1 수용체 작용제의 골대사에 대한 영향: 주로 제1세대 약물의 무작위 위약 대조 임상시험에 대한 체계적 문헌고찰 및 메타분석

The effect of glucagon-like peptide-1 receptor agonists on bone metabolism: A systematic review and meta-analysis of randomized placebo-controlled trials of predominantly first-generation agents

European journal of medical genetics2026-11-02

듀센형 근디스트로피의 엑손 스키핑 치료법의 효능 및 안전성: 체계적 문헌고찰

Efficacy and safety of exon skipping therapies for Duchenne Muscular Dystrophy: A Systematic Review

Critical reviews in oncology/hematology2026-11-02

유방암의 세포 기반 및 유전자 기반 치료: 현재 접근법, 임상 결과, 향후 전망

Breast cancer cellular and gene-based therapies: current approaches, clinical results, and future perspectives

Life sciences2026-11-02

P2Y6R은 췌장암 악액질에서 지방 조직 염증 및 근육 소모와 연관된다

P2Y6R is associated with adipose inflammation and muscle wasting in pancreatic cancer cachexia

Cell2026-11-02

산업화 구배에 따른 인간 장내 세균의 수렴적 게놈 진화

Convergent genomic evolution of human gut bacteria along an industrialization gradient

Cell2026-11-02

산업화는 인간 메타유기체에서 수렴적 미생물군집 및 숙주 생리 변화를 야기한다

Industrialization drives convergent microbiome and host physiological shifts in the human metaorganism

Journal of medical Internet research2026-11-02

AI가 항생제 내성과 싸우기 위한 약물 재창출에 도움이 될 수 있는가?

Can AI Help Repurpose Drugs to Fight Against Antibiotic Resistance?

Journal of the National Cancer Institute2026-11-02

항체-약물 복합체의 효능: 올바른 치료 효과를 측정하고 있는가?

Antibody drug conjugate efficacy: are we measuring the right treatment effect?

PLoS biology2026-11-02

박테리아 대사산물-활성화 인간 장내 γδT세포에 의한 곰팡이 억제가 크론병에서 손상된다

Fungal suppression by bacterial metabolite-activated human intestinal γδT-cells is disrupted in Crohn's disease

Ocular immunology and inflammation2026-11-02

T세포-표적화 이중특이성 치료법과 안구 염증: 새로운 표현형, 면역학적 메커니즘, 및 임상 관리

T-Cell-Engaging Bispecific Therapies and Ocular Inflammation Emerging Phenotypes, Immunologic Mechanisms, and Clinical Management

Molecular biomedicine2026-11-02

비열 아르곤 플라즈마 치료가 각질세포 산화 스트레스 감소를 통해 아토피 피부염을 완화

Non-thermal argon plasma therapy alleviates atopic dermatitis by reducing keratinocyte oxidative stress

International journal of hematology2026-11-02

지속 가능한 CAR-T 세포 치료를 지지하는 실제 근거: 접근성에서 장기 추적관찰까지

Real-world evidence supporting sustainable CAR-T-cell therapy-from access to long-term follow-up

Journal of the National Cancer Institute2026-11-02

당단백질 비전이성 흑색종 단백질 B 과발현: 사이클린 의존 키나제 4/6 억제제 내성의 마커

Glycoprotein nonmetastatic melanoma protein B overexpression-a marker of resistance to cyclin-dependent kinase 4 and 6 inhibitors

Indian journal of pharmacology2026-11-02

티르제파타이드 관련 심각한 등용적 저나트륨혈증: 항이뇨호르몬 부적절 분비 증후군과 부합하는 생화학적 특징

Tirzepatide-associated severe euvolemic hyponatremia with syndrome of inappropriate antidiuretic hormone secretion-compatible biochemical features

Indian journal of pharmacology2026-11-02

피노레시놀 디글루코사이드의 1,2-디메틸히드라진 유도 대장암에 대한 화학보호 효과: NF-κB/유도성 일산화질소 합성효소/사이클로옥시게나제-2 신호 경로 및 장내 미생물 불균형 조절

Chemoprotective effect of pinoresinol diglucoside against 1,2-dimethylhydrazine-induced colorectal cancer through regulation of nuclear factor-kappa B/inducible nitric oxide synthase/cyclooxygenase-2 signaling and gut dysbiosis

Indian journal of pharmacology2026-11-02

고지방 식이 유도 동맥경화에 대한 고시핀의 보호 효과: PI3K/AKT/mTOR 경로 및 장내 미생물의 역할

Protective effect of gossypin against high-fat diet-induced atherosclerosis in rats: Role of the phosphoinositide 3-kinase/AKT/mechanistic target of rapamycin pathway and gut microbiota

Indian journal of pharmacology2026-11-02

아로마덴드린이 산화 스트레스, 세포사멸 및 MAPK/Nrf2 신호 경로 조절을 통해 이소프레나린 유도 심근 손상을 완화

Aromadendrin attenuates isoproterenol-induced myocardial injury via modulation of oxidative stress, apoptosis, and mitogen-activated protein kinase/nuclear factor erythroid 2-related factor 2 signaling pathways

Indian journal of pharmacology2026-11-02

스트렙토조토신 유도 당뇨 랫트에서 글리부라이드의 상처 치유 보호 효과: NF-κB/TGF-β 및 c-Jun/PDGF/VEGF 신호 경로의 변화를 통한

Protective effect of glyburide on wound healing in streptozotocin-induced diabetic rats via alteration of NF-κB/transforming growth factor-β and cellular jun/platelet-derived growth factor-vascular endothelial growth factor signaling pathways

Indian journal of pharmacology2026-11-02

아로마덴드린이 산화 스트레스, 염증 및 골 재형성 조절을 통해 덱사메타손 유도 골다공증을 완화

Aromadendrin attenuates dexamethasone-induced osteoporosis in rats by modulating oxidative stress, inflammation, and bone remodeling

Pain management2026-11-02

만성 통증의 새로운 생화학적 표적: 인도 맥락에서 분자 메커니즘과 공중보건 정책의 연결

Emerging biochemical targets in chronic pain: bridging molecular mechanisms and public health policy in the Indian context

Molecular pharmaceutics2026-11-02

[18F]AlF-NOTA-Asp2-티르제파타이드를 이용한 GLP-1 수용체 및 GIPR 이중 표적 PET 영상

PET Imaging of Dual GLP-1R and GIPR Targeting with [18F]AlF-NOTA-Asp2-Tirzepatide

Molecular pharmaceutics2026-11-02

CLDN18.2 표적 방사성 핵종 치료진단을 위한 89Zr/177Lu 표지된 공학 VHH 기반 항체의 전임상 연구

Preclinical Study of the 89Zr/177Lu-Labeled Engineered VHH-based Antibody for CLDN18.2-Targeted Radiotheranostics

Molecular pharmaceutics2026-11-02

GenMAS: ADMET 프로파일링을 위한 기계 학습 기반 모델링 및 평가 전략과 PBPK 시뮬레이션에의 적용

GenMAS: A Machine Learning-Based Modeling and Assessment Strategy for ADMET Profiling and its Application in PBPK Simulation

Molecular pharmaceutics2026-11-02

동역학적으로 제약된 하이브리드 신경 상미분방정식을 이용한 화학 구조로부터 마우스의 혈장 농도-시간 프로파일 예측

Prediction of Plasma Concentration-Time Profiles in Mice from Chemical Structure Using a Kinetically Constrained Hybrid Neural ODE

Molecular pharmaceutics2026-11-02

폐암 치료를 위한 TRAIL 치료법 재활성화에 리포폴리머를 통한 mRNA 전달

mRNA Delivery with Lipopolymers to Rejuvenate TRAIL Therapy for Lung Cancer Treatment

Molecular pharmaceutics2026-11-02

Repurposing Antibody-Drug Conjugates for Theranostic Targeting of Nectin-4 and TROP2 in Bladder Cancer

Molecular pharmaceutics2026-11-02

Preliminary Evaluation of Synthetic Amanitin Analogs as Novel Payloads for Potent Antibody-Drug Conjugates

Molecular pharmaceutics2026-11-02

Characterization of a 64Cu-Labeled Heterobivalent Bicyclic Peptide (Nectin-4/Albumin) for Targeting of Tumor-Associated Nectin-4

Molecular pharmaceutics2026-11-02

Radiohalogenated Tetrazines for Click Chemistry-Mediated Pretargeted Radioimmunotherapy

Molecular pharmaceutics2026-11-02

First-in-Human PET/CT Imaging of FXX489, a Second-Generation Cyclic Peptide FAP Inhibitor: A Translational Exploratory Study

Molecular pharmaceutics2026-11-02

Dual Antifibrotic Modulation via CTGF Silencing and Peptide Amphiphile Nanofibers for Topical Treatment of Skin Fibrosis

Molecular pharmaceutics2026-11-02

Iron Boride Nanostructures as Oral Acid-Responsive Hydrogen Donors for Alzheimer's Disease Therapy

Molecular pharmaceutics2026-11-02

Molecular Dynamics Simulation-Guided 124I/211At-Labeled Aromatic Amide Derivatives as a Potential Theranostic Pair for Melanoma

Balkan medical journal2026-11-02

GLP-1 Receptor Agonists Versus Empagliflozin or Dapagliflozin in the MASLD-Heart Failure Phenotype: An Exploratory Propensity-Matched Cohort Study

Journal of veterinary internal medicine2026-11-02

Bendamustine induces peripheral lymphodepletion in dogs with relapsed lymphoma